From gangrenous infections to lepers losinglimbs, here are the 5 most painful skin diseases ever. Today's topic was requested by Pablito's Way. If you have any other topics you'd like tolearn about, subscribe and let us know in the comments section below. Number 5: GangreneGangrene is a life threatening condition caused by either insufficient blood supply or byan infection of the skin. This lack of blood supply results in the debtof tissue cells and causes the skin to dry
up, become discolored, and eventually falloff. There are multiple types of gangrene and ifnot treated properly, are very deadly as each type is capable of damaging vital organs. The first type of gangrene is dry gangrene. This is often caused by a lack of blood supplyto a particular area of the body. Typically, it affects the hands and feet asa result of poor blood circulation. The tissue will often dry up, become discolored,then fall off! The next type is wet gangrene, which is theresult of an infected area.
Wet gangrene is usually associated with aninjury such as a burn or gunshot wound. It is generally more dangerous of the twobecause it can spread very quickly throughout the body. Symptoms include blisters with foul smellingdischarge, swelling, intense pain, dry skin, fevers, and if untreated, debt. There is also gas gangrene, which is far lesscommon than the other two and is often caused by the clostridium bacteria that affects themuscles. It can additionally cause a person to experienceseptic shock and lowered blood pressure.
Confusion, body rashes, pain, rapid heartbeat,and light headedness are all common symptoms of this type. Gangrene has been documented as far back as1194 AD, when Duke Leopold of Austria had his foot crushed by his horse. Once the foot was infected, his surgeons advisedhim to have it amputated. It took them three tries to do so successfully,however, and after he likely suffered more injuries, he contracted wet gangrene and eventuallydyed. The disease was not widespread until the 19thcentury during the American Civil War.
Fought between 1861 and 1865, the war wasa bloody affair, claiming the lives of 750,000 soldiers. By some estimates, gangrene was responsiblefor nearly 400,000 of those debts. Soldiers on both sides were subjected to poormedical facilities and practices. s mistakenly would use dirty hands andinstruments to operate on patients, which resulted in the fast spread of gangrene. During this time, it became known as â€œgangrene.â€� In most cases, soldiers dyed after contractingthe wet gangrene type.
A similar problem was presented in World WarI when soldiers began contracting â€œtrench foot.â€� World War I was known for its use of trenches,and where soldiers often spent long hours inside these trenches during battle. The long hours and even days spent in thetrenches' unsanitary conditions often resulted in the development of gangrene, which alsocaused sensory nerve damage, inflammation, and frostbite. Number 4: LeprosyLeprosy is a chronic infection caused by two
The Immune System Explained I Bacteria Infection
Narrator: Every second of your life youare under attack. Billions of bacteria, viruses, and fungi are trying to make youtheir home. So our bodies have developed a super complex little army with guards,soldiers, intelligence, weapons factories and communicators to protect you from uh,well, dying. For this tutorial, let's assume the immune system has twelve different jobs. For example, kill enemies, communicate etc. And it has 21 different cells and twoprotein forces. These cells have up to four different jobs. Let's assign them. Here are the interactions. Now let's make this understandable. First of all, let's addcolors to the jobs. Now let's illustrate
the cells. The central color represents the main job of the cell, while the surrounding ones represent secondary duties. Now the immune system looks like this. Now the interactions. Isn't this complexity just awesomeé For this tutorial we will only talk about these cells and ignore the rest. So what happens in the case of an infectioné Music It's a beautiful day when suddenly a wild rusty nail appears and you cut yourself. The first barrier of the immune system isbreached: your skin. Nearby bacteria sieze
on the opportunity and enter your wound.They start using up the body's resources and double their numbers about every 20 minutes. At first they fly under the radar but when a certain bacteria population isreached, they change their behavior and start to damage the body by changing the environment around them. The immune system has to stop them as fast as possible. First of all your guard cells, known as macrophages, intervene. They are huge cells that guard every border region of the body. Most of the time they alone cansuffocate an attack because they can devour up to 100 intruders each. They swallow the intruder whole and trap it inside a membrane.
Then the enemy gets broken down by enzymesand is killed. On top of that, they cause inflammation by ordering the blood vesselsto release water into the battlefield so fighting becomes easier. You notice this as a very mild swelling. When the macrophages fight for too long, they call in heavy backup by releasing messenger proteins that communicate location and urgency. Neutrophiles leave their patrol routes in the blood and move to the battlefield. TheNeutrophiles fight so furiously that they kill healthy cells in the process. On top of that, they generate barriers that trap and kill the bacteria. They are indeed so deadly that they evolved to commit suicide
after five days to prevent them from causing too much damage. If this is not enough to stop the invasion, the brain of the immune system kicks in. The dendritic cell gets active. It reacts to the signals of the soldiers and starts collecting samples from the enemies. They rip them into piecesand present the parts on their outer layer. Now, the dendritic cell makes a crucial decision. Should they call for antivirus forces that eradicate infected body cells,or an army of bacteria killersé In this case, antibacteria forces are necessary.It then travels to the closest lymph node in about a day. Here billions of helper andKillerT cells are waiting to be activated.
When TCells are born they go through adifficult and complicated training process and only a quarter survives. The survivingcells are equipped with a specific setup. And the dendritic cell is on its way lookingfor a helper Tcell with a set up that's just right. It's looking for a helper Tcellthat combines the parts of the intruders which the dendritic cell has presented on its membrane. When it finally finds one, a chain reaction takes place. The helper Tcell is activated. It quickly duplicates thousands of times. Some become memory Tcells that stay in the lymph node and will make you practically immune to this enemy.Some travel to the field of battle to help